Padlocks, Chains, and Other Locks

Aside from Locks Which Require Specific Solutions, You'll Encounter Several Other Types of Containers While Playing as Both Jill and Carlos. Pretty Much All of These Can Be Unlocked by Using Key Items Found Throughout the Game, and You'll Know When You Don't Need Those Key Items Anymore Because Your Inventories Will Say They Can Be Discarded.

The Safe in Downtown Raccoon City Is the First of Its Kind That Players Will Come Across and Is Therefore the First Place Players Should Look to Get an Early-Game Advantage. If You Played Through the Demo of the Game, You'll Know What's in It and Where to Find It, but for Those Who Aren't Sure, Head to the Upstairs Area Across from the Pharmacy When You First Start Exploring Raccoon City as Jill.

Jill Only Has the One Safe to Open in Raccoon City, So for the Rest of the Locked Containers, You'll Be Playing as Carlos When You Open Them. the First Puzzle for Carlos to Unravel Is in the Shower Room Within the Police Station Which Is Where Players Explore When They're First Able to Play as Carlos.

Downstairs in the Police Station Is Another Safe Within the West Office. If You Played Resident Evil 2, You May by Now Be Noticing a Trend. the Safes and Lockers Are in the Same Spot as They Were in the First Remake, and the Solutions to These Puzzles Are Also the Same.

Third Floor Hallway Locker

Back up on the Third Floor of the Police Station, There's One More Puzzle to Open in This Building. It's a Locker at the End of the Hallway with Another Combination Lock That Requires Players to Input the Correct Series of Letters to Unlock It.

Your Final Safe to Crack in Resident Evil 3 Is Also One of the Toughest Ones to Open Because of How Well the Combination to the Safe Is Hidden. It's Located Again When You're Playing as Carlos, but You'll Find This One in the Hospital Level Instead of in the Police Station.

How to Open Every Safe and Lock

By Alexander Ross

• Oct 8, 2026 • 7 min read

Direct Answer • Key Takeaway

Like Most Resident Evil Games, Resident Evil 3 Hides Many of Its Best Rewards and Upgrades Behind Locked Containers and Puzzles. These Locked Containers Can Take the Form of a Safe, a Locker, or Cases Requiring Certain Keys to Open, but Each of Them Are Worth Looking into Since You Never Know Whether It'll Just Contain Some Ammo of If They Hold Permanent Upgrades for Your Gear. to Take the Guesswork out of What's in the Most Puzzling Containers Throughout Resident Evil 3, We've Put Together a Guide for How to Unlock Every Single Safe and Other Type of Container Throughout the Game.

Alexander Ross

Gaming, Esports & Interactive Media Writer

Alexander Ross has covered the video game industry for a decade, writing deep dives on game design, esports tournaments, VR developments, and gaming culture.

Tags: resident evil 3 how to open every safe lock